Identification of domains conferring G protein regulation on inward rectifier potassium channels

@article{Kunkel1995IdentificationOD,
  title={Identification of domains conferring G protein regulation on inward rectifier potassium channels},
  author={M. T. Kunkel and E. Peralta},
  journal={Cell},
  year={1995},
  volume={83},
  pages={443-449}
}
  • M. T. Kunkel, E. Peralta
  • Published 1995
  • Biology, Medicine
  • Cell
  • Cardiac m2 muscarinic acetylcholine receptors reduce heart rate by coupling to heterotrimeric (alpha beta gamma) guanine nucleotide-binding (G) proteins that activate IKACh, an inward rectifier K+ channel (IRK). Activation of the GIRK subunit of IKACh requires G beta gamma subunits; however, the structural basis of channel regulation is unknown. To determine which sequences confer G beta gamma regulation upon IRKs, we generated chimeric proteins composed of GIRK and RB-IRK2, a related, G… CONTINUE READING
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