Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbit.

@article{Tynes1985IdentificationOD,
  title={Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbit.},
  author={Ronald E. Tynes and P J Sabourin and Ernest Hodgson},
  journal={Biochemical and biophysical research communications},
  year={1985},
  volume={126 3},
  pages={1069-75}
}
The flavin-containing monooxygenase has been purified from mouse and rabbit lung microsomes and shown to be distinct from the flavin-containing monooxygenase found in the liver of the same species. The mouse and rabbit lung monooxygenases have a unique ability to N-oxidize the primary aliphatic amine, n-octylamine, commonly included in microsomal incubations to inhibit cytochrome P-450. In the mouse lung, this compound not only serves as a substrate but is also a positive effector of metabolism… CONTINUE READING

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