Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins.

@article{Garrett1989IdentificationOD,
  title={Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins.},
  author={Michelle Dawn Garrett and Annette Self and Casper A. M. M. van Oers and Alan G Hall},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 1},
  pages={10-3}
}
The protein products of the mammalian ras genes, p21ras, are regulatory guanine nucleotide binding proteins that are involved in the control of cell proliferation, though the exact biochemical processes regulated are unknown. Recently a cytoplasmic protein has been identified that interacts with and increases the GTPase activity of p21ras. It has been shown that this GTPase-activating protein, or GAP, interacts with the effector domain of ras, leading us and others to propose that GAP may be… CONTINUE READING