Identification of dihydropyridines that reduce cellular tau levels.

@article{Evans2011IdentificationOD,
  title={Identification of dihydropyridines that reduce cellular tau levels.},
  author={Christopher G Evans and Umesh K. Jinwal and Leah N Makley and Chad A Dickey and Jason E. Gestwicki},
  journal={Chemical communications},
  year={2011},
  volume={47 1},
  pages={529-31}
}
A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.