Identification of differentially methylated loci using wavelet-based functional mixed models

  title={Identification of differentially methylated loci using wavelet-based functional mixed models},
  author={Wonyul Lee and Jeffrey S. Morris},
  volume={32 5},
MOTIVATION DNA methylation is a key epigenetic modification that can modulate gene expression. Over the past decade, a lot of studies have focused on profiling DNA methylation and investigating its alterations in complex diseases such as cancer. While early studies were mostly restricted to CpG islands or promoter regions, recent findings indicate that many of important DNA methylation changes can occur in other regions and DNA methylation needs to be examined on a genome-wide scale. In this… CONTINUE READING
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