Identification of differentially expressed thyroid hormone responsive genes from the brain of the Mexican Axolotl (Ambystoma mexicanum).

@article{Huggins2012IdentificationOD,
  title={Identification of differentially expressed thyroid hormone responsive genes from the brain of the Mexican Axolotl (Ambystoma mexicanum).},
  author={P Huggins and Carlena K Johnson and Angela Sch{\"o}rgendorfer and Srikrishna Putta and Arne C. Bathke and Arnold J. Stromberg and Stephen Randal Voss},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2012},
  volume={155 1},
  pages={128-35}
}
The Mexican axolotl (Ambystoma mexicanum) presents an excellent model to investigate mechanisms of brain development that are conserved among vertebrates. In particular, metamorphic changes of the brain can be induced in free-living aquatic juveniles and adults by simply adding thyroid hormone (T4) to rearing water. Whole brains were sampled from juvenile A. mexicanum that were exposed to 0, 8, and 18 days of 50 nM T4, and these were used to isolate RNA and make normalized cDNA libraries for… CONTINUE READING
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