Identification of differentially expressed proteins in human glioblastoma cell lines and tumors.

@article{Zhang2003IdentificationOD,
  title={Identification of differentially expressed proteins in human glioblastoma cell lines and tumors.},
  author={Rulin Zhang and T L Tremblay and Angela McDermid and Pierre Thibault and Danica D Stanimirovic},
  journal={Glia},
  year={2003},
  volume={42 2},
  pages={194-208}
}
An in-frame deletion of 801 bp in exons 2-7 (type III mutation) of the epidermal growth factor receptor (EGFR) is detected at high incidence in primary glioblastoma tumors. A proteomic approach was used to generate differential protein expression maps of fetal human astrocytes (FHA), human glioblastoma cell lines U87MG and U87MG expressing type III EGFR deletion (U87MGdeltaEGFR) that confers high malignancy to tumor cells. Two-dimensional gel electrophoresis followed by in-gel digestion of… CONTINUE READING

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