Identification of different roles for RanGDP and RanGTP in nuclear protein import.

@article{Grlich1996IdentificationOD,
  title={Identification of different roles for RanGDP and RanGTP in nuclear protein import.},
  author={Dirk G{\"o}rlich and Nelly Pant{\'e} and Ulrike Kutay and Ueli Aebi and Francis Bischoff},
  journal={The EMBO journal},
  year={1996},
  volume={15 20},
  pages={
          5584-94
        }
}
The importin-alpha/beta heterodimer and the GTPase Ran play key roles in nuclear protein import. Importin binds the nuclear localization signal (NLS). Translocation of the resulting import ligand complex through the nuclear pore complex (NPC) requires Ran and is terminated at the nucleoplasmic side by its disassembly. The principal GTP exchange factor for Ran is the nuclear protein RCC1, whereas the major RanGAP is cytoplasmic, predicting that nuclear Ran is mainly in the GTP form and… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

importin subunits in nuclear protein import

  • D. Gorlich, P. Henklein, R. A. Laskey, E. Hartmann
  • 1996
Highly Influential
4 Excerpts

Evidence using a

  • K. L. Carey, S. A. Richards, K. M. Lounsbury, I. G. Macara
  • 1996
1 Excerpt

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