Identification of deletion mutations and three new genes at the familial polyposis locus.

@article{Joslyn1991IdentificationOD,
  title={Identification of deletion mutations and three new genes at the familial polyposis locus.},
  author={Geoffrey Joslyn and M. Carlson and Andrew Thliveris and Hans M. Albertsen and Lawrence Gelbert and Wade S. Samowitz and Joanna Groden and James Stevens and Lisa N. Spirio and Margaret Robertson},
  journal={Cell},
  year={1991},
  volume={66 3},
  pages={601-13}
}
Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in… CONTINUE READING

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