Identification of dehydroabietc acid from Boswellia thurifera resin as a positive GABAA receptor modulator.

Abstract

In a two-microelectrode voltage clamp assay with Xenopus laevis oocytes, a petroleum ether extract (100 μg/mL) of the resin of Boswellia thurifera (Burseraceae) potentiated GABA-induced chloride currents (IGABA) through receptors of the subtype α₁β₂γ₂s by 319.8% ± 79.8%. With the aid of HPLC-based activity profiling, three known terpenoids, dehydroabietic… (More)
DOI: 10.1016/j.fitote.2014.09.002

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