Identification of degradation products of saquinavir mesylate by ultra-high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry and its application to quality control.

Abstract

RATIONALE Saquinavir mesylate (SQM) is an antiviral drug used for the treatment of HIV infections. The identification and characterization of all degradation products are essential for achieving the quality in pharmaceutical product development and also for patient safety. METHODS The drug was subjected to hydrolytic (HCl, NaOH and water), oxidative (H2… (More)
DOI: 10.1002/rcm.7842

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