Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.

@article{Nakagawa2004IdentificationOD,
  title={Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.},
  author={Taku Nakagawa and Yoji Hayashita and Ken Maeno and Akira Masuda and Nobuyoshi Sugito and Hirotaka Osada and Kiyoshi Yanagisawa and Hiromichi Ebi and Kaoru Shimokata and Takashi Takahashi},
  journal={Cancer research},
  year={2004},
  volume={64 14},
  pages={4826-32}
}
It has been suggested that attenuation of the decatenation G(2) checkpoint function, which ensures sufficient chromatid decatenation by topoisomerase II before entering into mitosis, may contribute to the acquisition of genetic instability in cancer cells. To date, however, very little information is available on this type of checkpoint defect in human cancers. In this study, we report for the first time that a proportion of human lung cancer cell lines did not properly arrest before entering… CONTINUE READING