Identification of cytotoxic T lymphocyte epitopes of human herpesvirus 8.

@article{Micheletti2002IdentificationOC,
  title={Identification of cytotoxic T lymphocyte epitopes of human herpesvirus 8.},
  author={Fabiola Micheletti and Paolo Monini and Cinzia Fortini and Paola Rimessi and Martina Bazzaro and Massimo Andreoni and Massimo Giuliani and Serena Traniello and Barbara Ensoli and Riccardo Gavioli},
  journal={Immunology},
  year={2002},
  volume={106 3},
  pages={395-403}
}
The human herpesvirus 8 (HHV-8) is a human gamma2-herpesvirus that is implicated in the development of Kaposi's sarcoma (KS), primary effusion lymphoma and Castelman's disease. Since the responses of cytotoxic T lymphocytes (CTL) play a key role in the control of herpesvirus infection, it is important to identify and to characterize the CTL target epitopes of HHV-8 viral antigens. In this study, using peptide-binding motifs, we selected potential human leucocyte antigen (HLA)-A2-binding… CONTINUE READING
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