Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7.

@article{Strassburg2001IdentificationOC,
  title={Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7.},
  author={Christian P. Strassburg and A. O. Barut and Petra Obermayer-Straub and Qi Li and Nick Nguyen and Robert H. Tukey and Michael P. Manns},
  journal={Journal of hepatology},
  year={2001},
  volume={34 6},
  pages={865-72}
}
BACKGROUND/AIMS The oral administration of the major transplant immunosuppressants cyclosporine A and tacrolimus leads to unpredictable drug levels requiring drug monitoring. Hepatic and extrahepatic metabolism of cyclosporine A and tacrolimus by cytochrome P450 proteins has been analyzed but metabolism and inactivation by glucuronidation has not been investigated. METHODS Cyclosporine A and tacrolimus glucuronidation was measured in hepatic and gastrointestinal microsomal protein, and with… CONTINUE READING

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