Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.

@article{Forseth2011IdentificationOC,
  title={Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.},
  author={Ry R. Forseth and Ellen M Fox and Dawoon Chung and Barbara J. Howlett and Nancy P Keller and Frank C Schroeder},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 25},
  pages={9678-81}
}
Gliotoxin, a major product of the gli non-ribosomal peptide synthetase gene cluster, is strongly associated with virulence of the opportunistic human pathogen Aspergillus fumigatus. Despite identification of the gli cluster, the pathway of gliotoxin biosynthesis has remained elusive, in part because few potential intermediates have been identified. In addition, previous studies suggest that knowledge of gli-dependent metabolites is incomplete. Here we use differential analysis by 2D NMR… CONTINUE READING

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