Identification of cross-reactivity between buckwheat and coconut.


A PubMed literature review found only one similar case in which a patient in Thailand had chronic allergic angioedema caused by ingesting navel oranges but not other fruits of the Citrus genus.4 The possibility of other cases of such specific allergy existing is undeniable, but the reported incidence is clearly rare, potentially indicating misdiagnoses or underreporting. The clinical data from the study by Iorio et al5 reveals that citrus allergy is not a very rare condition in patients who are sensitized to pollen,5 which is the underlying condition in patients with oral allergy syndrome. Furthermore, these researchers5 indicated that lipid transfer proteins (LTPs) were, as allergens, correlated with systemic symptoms, such as this patient’s anaphylaxis. Thus, the anaphylaxis could be explained by a sensitization to a C clementina LTP, categorically known as Cit cl 3, which is not cross-reactive with LTPs expressed in the phenotype of either C reticulata or C sinensis.

DOI: 10.1016/j.anai.2015.09.008

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Cite this paper

@article{Cifuentes2015IdentificationOC, title={Identification of cross-reactivity between buckwheat and coconut.}, author={Liliana Cifuentes and Gianni Mistrello and Stefano Amato and Antonia Kolbinger and Mahzad Ziai and Markus W. Ollert and Davide Pennino and J. Ring and Ulf Darsow and Enrico Heffler}, journal={Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology}, year={2015}, volume={115 6}, pages={530-2} }