Identification of cross‐reaction patterns in allergic contact dermatitis from topical corticosteroids

@article{Coopman1989IdentificationOC,
  title={Identification of cross‐reaction patterns in allergic contact dermatitis from topical corticosteroids},
  author={Serge A. Coopman and H. Degreef and A. Dooms‐goossens},
  journal={British Journal of Dermatology},
  year={1989},
  volume={121}
}
Contact allergy to topical corticosteroids occurs more frequently than previously supposed. Cross‐allergic phenomena are common. On the basis of a review of the literature and our own patch test data on 15 patients, we conclude that positive patchtests to corticosteroids occur approximately six to seven times more frequently in well‐defined groups of structurally‐related substances than between corticosteroids of different groups. An analogous substitution pattern on the steroid D‐ring or the… 
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292 Citations
Highly Influential Citations
5
Background Citations
36
Methods Citations
6

292 Citations

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Citation Type

Contact allergies to topical corticosteroids: 10 cases of contact dermatitis
TLDR
Patients who noticed worsening of their skin disease after using topical corticosteroid preparations were patch tested both with the commercial preparation and the Corticosteroids itself, finding a true cross‐reaction between budesonide and hydrocortisone butyrate was found and all 9 patients showed further sensitivities to other cortICosteroids.
Allergic contact dermatitis from topical corticosteroid preparations
TLDR
It is still appropriate to test suspected corticosteroid allergic patients with their own topical steroid, the standard screening tray, and the vehicle and preservative tray in addition to screening with markers such as tixocortol pivalate to identify topical steroids that they may tolerate.
Contact hypersensitivity to topical corticosteroids
TLDR
The value of TP as a marker of corticosteroid hypersensitivity is reinforced by this study, but no satisfactory marker was found for the 9·2% of cases not detected by TP.
Corticosteroid classes: a quick reference guide including patch test substances and cross-reactivity.
TLDR
With broad and vast utilization, it stands to reason that corticosteroids became recognized as the American Contact Dermatitis Society’s 2005 allergen of the year.
Cross‐reactivity patterns to budesonide
TLDR
Patients positive to budesonide should therefore avoid hydrocortisone and triamcinolone acetonide, and patch testing, unfortunately, is an inaccurate method of determining cross‐reactivity patterns among corticosteroids.
Allergic Contact Dermatitis from Corticosteroids: Reproducibility of Patch Testing and Correlation with Intradermal Testing
TLDR
Patch testing is sufficient in diagnosing allergic contact dermatitis from topical steroids, and testing with commercial products is not a good screen for steroid allergy.
Allergic contact dermatitis following ocular use of corticosteroids.
  • M. Baeck, P. De Potter, A. Goossens
  • Medicine
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • 2011
TLDR
Ophthalmic CSs, despite their anti-inflammatory and antiallergic properties, may produce contact-allergic reactions following ocular use of corticosteroid preparations.
Reactions to other corticosteroids in patients with allergic contact dermatitis from hydrocortisone
TLDR
The data found that the presence of a substitution at the C6 or C9 position was the most important factor in determining whether a patient would be allergic to another corticosteroid.
Delayed allergic hypersensitivity to corticosteroids: Diagnosis and cross-reactivity
TLDR
Dendrogram analysis, which classifies corticosteroids in function of their electrostatic and steric fields, and comparison with the clinical data has identified two different types of patients, based on their recognizing the molecules differently, and a modified classification is proposed.
Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids.
TLDR
The statistical analysis confirms that tixocortol pivalate and hydrocortisone contact allergies are definitely associated, while reactions to budesonide are strongly correlated with the reactions to both the acetonide group and the ester group.
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