Identification of cross‐reaction patterns in allergic contact dermatitis from topical corticosteroids

  title={Identification of cross‐reaction patterns in allergic contact dermatitis from topical corticosteroids},
  author={Serge A. Coopman and H. Degreef and A. Dooms‐goossens},
  journal={British Journal of Dermatology},
Contact allergy to topical corticosteroids occurs more frequently than previously supposed. Cross‐allergic phenomena are common. On the basis of a review of the literature and our own patch test data on 15 patients, we conclude that positive patchtests to corticosteroids occur approximately six to seven times more frequently in well‐defined groups of structurally‐related substances than between corticosteroids of different groups. An analogous substitution pattern on the steroid D‐ring or the… 

Allergic Contact Dermatitis to Corticosteroids

This review summarizes current state of knowledge of allergic contact dermatitis to corticosteroids and highlights recent findings in this field. Tixocortol-21-pivalate and budesonide are the most

Contact allergies to topical corticosteroids: 10 cases of contact dermatitis

Patients who noticed worsening of their skin disease after using topical corticosteroid preparations were patch tested both with the commercial preparation and the Corticosteroids itself, finding a true cross‐reaction between budesonide and hydrocortisone butyrate was found and all 9 patients showed further sensitivities to other cortICosteroids.

Contact hypersensitivity to topical corticosteroids

The value of TP as a marker of corticosteroid hypersensitivity is reinforced by this study, but no satisfactory marker was found for the 9·2% of cases not detected by TP.

Corticosteroid classes: a quick reference guide including patch test substances and cross-reactivity.

Cross‐reactivity patterns to budesonide

Patients positive to budesonide should therefore avoid hydrocortisone and triamcinolone acetonide, and patch testing, unfortunately, is an inaccurate method of determining cross‐reactivity patterns among corticosteroids.

Allergic Contact Dermatitis from Corticosteroids: Reproducibility of Patch Testing and Correlation with Intradermal Testing

Patch testing is sufficient in diagnosing allergic contact dermatitis from topical steroids, and testing with commercial products is not a good screen for steroid allergy.

Allergic contact dermatitis following ocular use of corticosteroids.

  • M. BaeckP. De PotterA. Goossens
  • Medicine
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • 2011
Ophthalmic CSs, despite their anti-inflammatory and antiallergic properties, may produce contact-allergic reactions following ocular use of corticosteroid preparations.

Reactions to other corticosteroids in patients with allergic contact dermatitis from hydrocortisone

The data found that the presence of a substitution at the C6 or C9 position was the most important factor in determining whether a patient would be allergic to another corticosteroid.



Contact sensitivity to topical corticosteroids.

  • J. Guin
  • Medicine
    Journal of the American Academy of Dermatology
  • 1984

Identification of undetected corticosteroid allergy

The anti-mflammatory effect of corticosterOids may mask contact allergy and falsenegative results on patch testing may further detect cross-reactions, which are comparable to the frequency of contact allergy to formaldehyde and parahens m the authors' patch-tested patients.

Allergic contact eczema from topical corticosteroids

Eptcutaneous tests with topical steroids in therapeutic and ten‐fold therapeutic concentrations in ethanol were performed in 105 patients selected on the basis of unresponsiveness of their eczema to

Delayed hypersensitivity to topical corticosteroids.

Contact allergy to the corticosteroid budesonide

A 39-year-old lady presented on January 28, 1980 with edematous and erythematous plaques on the inner aspect of the thighs, knees and elbows and a dermatitis developed 2 days after the first application of the new corticosteroid ointment called Preferid® for psoriasis.

Allergic contact dermatitis and conjunctivitis to corticosteroids

Two patients suspected of having allergic dermato‐conjunctivitis showed positive allergic patch test reactions to the respective corticosteroid betamethasonc valerate, and one to hydrocortisone, neomycin, and a rubber additive.

Contact dermatitis from Emulgin RO/40, an emulsifier in Hioxyl cream

Tlus appears to be the first proven case of contact allergy to metipranolol reported, and the significance of t!us finding IS uncertam is unclear.

Cross‐reactions in topical corticosteroid contact dermatitis

2. Pevny I. CerumenexTM allergy. 3. De Padova M P, Bardazzi F, Vassilopoulou A, Lama L.

Contact allergic reaction to valerate esters of betamethasone and hydrocortisone

  • E. Koch
  • Medicine
    Contact dermatitis
  • 1985
In a 29-year-old female nurse, some vesicles and redness were noted on the 3rd day of the trial, only on the area of the forearm treated with 0.1 % betamethsone-17-valerate cream, and the eruption completely subsided within 5 days after discontinuing the trial.

Allergic contact dermatitis to topical corticosteroids: clobetasol propionate and clobetasone butyrate

Two patients with positive patch test reactions to clobetasol propionate and 30 other steroids that were chemically very closely related to these two 2l‐chloro‐9‐α‐fluoro‐corticosteroids, were patch test negative.