Identification of critical residues within the conserved and specificity patches of nerve growth factor leading to survival or differentiation.

@article{Mahapatra2009IdentificationOC,
  title={Identification of critical residues within the conserved and specificity patches of nerve growth factor leading to survival or differentiation.},
  author={Sidharth Mahapatra and Hrishikesh M. Mehta and Sang Bum Woo and Kenneth E. Neet},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 48},
  pages={
          33600-13
        }
}
Afflicted neurons in Alzheimer disease have been shown to display an imbalance in the expression of TrkA and p75(NTR) at the cell surface, and administration of nerve growth factor (NGF) has been considered and attempted for treatment. However, wild-type NGF causes extensive elaboration of neurites while providing survival support. This study was aimed at developing recombinant NGF muteins that did not support neuritogenesis while maintaining the survival response. Critical residues were… CONTINUE READING

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