Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.

@article{Malherbe2003IdentificationOC,
  title={Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.},
  author={Pari Malherbe and Vincent Mutel and Clemens Broger and Florent Perin-Dureau and John A. Kemp and Jacques Neyton and Pierre Paoletti and James N. C. Kew},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={307 3},
  pages={897-905}
}
N-Methyl-d-aspartate (NMDA) receptors play key roles in both physiological processes, particularly synaptic plasticity, and in neuropathological states such as epilepsy and acute neurodegeneration. R-(R*,S*)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenyl-methyl)-1-piperidine propanol (RO 25-6981), is a high-affinity and selective blocker of NMDA receptors containing the NR2B subunit. Using site-directed mutagenesis, [3H]RO 25-6981 binding, Xenopus oocyte voltage-clamp recordings, and molecular… CONTINUE READING

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