Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression.

@article{Datson2001IdentificationOC,
  title={Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression.},
  author={Nicole A Datson and J van der Perk and Edo Ronald de Kloet and E. Vreugdenhil},
  journal={The European journal of neuroscience},
  year={2001},
  volume={14 4},
  pages={675-89}
}
Adrenal corticosteroids (CORT) have a profound effect on the function of the hippocampus. This is mediated in a coordinated manner by mineralocorticoid (MR) and glucocorticoid receptors (GR) via activation or repression of target genes. The aim of this study was to identify, using serial analysis of gene expression (SAGE), CORT-responsive hippocampal genes regulated via MR and/or GR. SAGE profiles were compared under different conditions of CORT exposure, resulting in the identification of 203… CONTINUE READING
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