Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.

@article{Lohuizen1991IdentificationOC,
  title={Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.},
  author={Maarten van Lohuizen and Sjef S Verbeek and Blanca Scheijen and Ellen Wientjens and Hanneke van der Gulden and Anton Berns},
  journal={Cell},
  year={1991},
  volume={65 5},
  pages={737-52}
}
Mo-MLV infection of E mu-myc transgenic mice results in a dramatic acceleration of pre-B cell lymphomagenesis. We have used provirus tagging to identify genes that cooperate with the E mu-myc transgene in B cell transformation. Here we report on the identification of four loci, pim-1, bmi-1, pal-1, and bla-1, which are occupied by proviruses in 35%, 35%, 28%, and 14% of the tumors, respectively. bmi-1, pal-1, and bla-1 represent novel common proviral insertion sites. The bmi-1 gene encodes a… CONTINUE READING

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