Identification of connective tissue growth factor as a target of WT1 transcriptional regulation.

@article{StanhopeBaker2000IdentificationOC,
  title={Identification of connective tissue growth factor as a target of WT1 transcriptional regulation.},
  author={Patricia Stanhope-Baker and Bryan R. G. Williams},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 49},
  pages={38139-50}
}
The Wilms tumor suppressor WT1 has transcription-activating and -suppressing capabilities. WT1-responsive promoters have been described; however, in large part, it remains unclear which potential downstream genes are physiologically relevant and mediate the function of WT1 in tumorigenesis and development. To identify genes regulated by WT1 in vivo, we used a dominant-negative version of WT1 to modulate WT1 activity in a Wilms tumor cell line. Screening oligonucleotide arrays with RNA from… CONTINUE READING
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