Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2

Abstract

Ubiquitin-like proteins (UBLs) modify targets via related E1-E2-E3 cascades. How is UBL conjugation fidelity established? Here we report the basis for UBL selection by UBL conjugating enzyme 12 (Ubc12), which is specific for the neural precursor cell expressed, developmentally down-regulated protein 8 (NEDD8), and does not form a thioester-linked conjugate… (More)
DOI: 10.1038/nsmb.1387

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