Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2.

@article{Covy2009IdentificationOC,
  title={Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2.},
  author={Jason P. Covy and Benoit I Giasson},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={378 3},
  pages={473-7}
}
Mutations in leucine-repeat rich kinase 2 (LRRK2) are the most common known cause of late-onset Parkinson's disease. In this study, a novel system to purify active recombinant LRRK2 expressed in mammalian cells was generated. This recombinant enzyme was used to characterize the specificity of LRRK2 and identify small compounds that can inhibit the kinase activity. Recombinant LRRK2 was shown to autophosphorylate and phosphorylate MBP and a peptide (LRRKtide) corresponding to the T558 [corrected… CONTINUE READING
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