Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen.

@article{Deeken2009IdentificationOC,
  title={Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen.},
  author={John F Deeken and Robert W. Robey and Suneet Shukla and Kenneth D. Steadman and Arup R. Chakraborty and Balasubramanian Poonkuzhali and Erin G. Schuetz and Susan L. Holbeck and Suresh V Ambudkar and Susan E Bates},
  journal={Molecular pharmacology},
  year={2009},
  volume={76 5},
  pages={946-56}
}
ABCG2 is an ATP-binding cassette transporter that counts multiple anticancer compounds among its substrates and is believed to regulate oral bioavailability as well as serve a protective role in the blood-brain barrier, the maternal-fetal barrier, and hematopoietic stem cells. We sought to determine whether novel compounds that interact with the transporter could be identified through analysis of cytotoxicity profiles recorded in the NCI Anticancer Drug Screen database. A flow cytometric assay… CONTINUE READING