Identification of common variants associated with human hippocampal and intracranial volumes

  title={Identification of common variants associated with human hippocampal and intracranial volumes},
  author={Jason L. Stein and Sarah E. Medland and Alejandro Arias V{\'a}squez and Derrek P. Hibar and Rudy E Senstad and Anderson M. Winkler and Roberto Toro and Katja Appel and Richard Barte{\vc}ek and {\O}rjan Bergmann and Manon Bernard and Andrew Anand Brown and Dara M. Cannon and M. Mallar Chakravarty and Andrea Nikie Christoforou and Martin Domin and Oliver Grimm and Marisa O. Hollinshead and Avram J. Holmes and Georg Homuth and Jouke-Jan Hottenga and Camilla Langan and Lorna M. Lopez and Narelle K. Hansell and Kristy S. Hwang and Sungeun Kim and Gonzalo E. Laje and Phil Hyoun Lee and Xinmin Liu and Eva Loth and Anbarasu Lourdusamy and Morten Mattingsdal and Sebastian Mohnke and Susana Mu{\~n}oz Maniega and Kwangsik Nho and Allison C. Nugent and Carol O'Brien and Martina Papmeyer and Benno Puetz and A. R. Sudamani Ramasamy and Jerod Rasmussen and Mark Rijpkema and Shannon L. Risacher and J. Cooper Roddey and Emma Jane Rose and Mina Ryten and Li Shen and Emma Sprooten and Eric Strengman and Alexander Teumer and Daniah Trabzuni and Jessica A. Turner and Kristel R. van Eijk and Theo G. M. van Erp and Marie-Jos{\'e} van Tol and Katharina Wittfeld and Christiane Wolf and Saskia Woudstra and Andr{\'e} Aleman and Saud Alhusaini and Laura Almasy and Elisabeth B. Binder and David G. Brohawn and Rita M. Cantor and Melanie A. Carless and Aiden P. Corvin and Michael Czisch and Joanne E. Curran and Gail Davies and Marcio Dias de Almeida and Norman Delanty and Chantal Depondt and Ravi K. Duggirala and Thomas D. Dyer and Susanne Erk and Jesen A. Fagerness and Peter T. Fox and Nelson B. Freimer and Michael Gill and Harald H. G{\"o}ring and Donald J. Hagler and David Hoehn and Florian Holsboer and Martine Hoogman and Norbert Hosten and Neda Jahanshad and Michael P. Johnson and Dalia Kasperavi{\vc}iūtė and Jack W. Kent and Peter Kochunov and Jack L. Lancaster and Stephen M Lawrie and David C M Liewald and R. Mandl and Mar Matarin and Manuel Mattheisen and Eva M. Meisenzahl and Ingrid Melle and E. K. Moses and Thomas W. M{\"u}hleisen and Matthias Nauck and Markus M. N{\"o}then and Rene L. Olvera and Massimo Pandolfo and G. Bruce Pike and Ralf Puls and Ivar Reinvang and Miguel E. Renteria and Marcella Rietschel and Joshua L. Roffman and Natalie A. Royle and Dan Rujescu and Jonathan Savitz and Hugo G. Schnack and Knut Schnell and Nina Seiferth and Colin Donald Smith and Vidar M. Steen and Maria del C. Vald{\'e}s Hern{\'a}ndez and Martijn P. van den Heuvel and Nic J. A. van der Wee and Neeltje E. M. van Haren and Joris A. Veltman and Henry V{\"o}lzke and Robert Kenyon Walker and Lars T. Westlye and Christopher D. Whelan and Ingrid Agartz and Dorret I. Boomsma and Gianpiero L Cavalleri and Anders M. Dale and Srdjan Djurovic and Wayne C. Drevets and Peter Hagoort and Jeremy Hall and Andreas Heinz and Clifford R. Jack and Tatiana Foroud and Stephanie Le Hellard and Fabio Macciardi and Grant W. Montgomery and Jean Baptiste Poline and David J. Porteous and Sanjay M. Sisodiya and John M. Starr and Jessika E. Sussmann and Arthur W. Toga and Dick J. Veltman and Henrik Walter and Michael W Weiner and Joshua C Bis and Mohammad A Ikram and Albert Vernon Smith and Vilmundur Gudnason and Christophe Tzourio and Meike W. Vernooij and Lenore J. Launer and Charles DeCarli and Sudha Seshadri},
  journal={Nature Genetics},
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance… CONTINUE READING


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