Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy.

  title={Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy.},
  author={Angela L. Zarling and Joy M. Polefrone and Anne M. Evans and Leann M Mikesh and Jeffrey Shabanowitz and Sarah T Lewis and Victor H Engelhard and Donald F. Hunt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 40},
Alterations in phosphorylation of cellular proteins are a hallmark of malignant transformation. Degradation of these phosphoproteins could generate cancer-specific class I MHC-associated phosphopeptides recognizable by CD8+ T lymphocytes. In a comparative analysis of phosphopeptides presented on the surface of melanoma, ovarian carcinoma, and B lymphoblastoid cells, we find 5 of 36 that are restricted to the solid tumors and common to both cancers. Differential presentation of these peptides… CONTINUE READING

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