Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.

@article{Marco1996IdentificationOC,
  title={Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.},
  author={A. Di Marco and I. Gloaguen and R. Graziani and G. Paonessa and I. Saggio and K. R. Hudson and Ralph Laufer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 17},
  pages={
          9247-52
        }
}
  • A. Di Marco, I. Gloaguen, +4 authors Ralph Laufer
  • Published 1996
  • Biology, Medicine, Geology
  • Proceedings of the National Academy of Sciences of the United States of America
  • Ciliary neurotrophic factor (CNTF) drives the sequential assembly of a receptor complex containing the ligand-specific alpha-receptor subunit (CNTFR alpha) and the signal transducers gp130 and leukemia inhibitory factor receptor-beta (LIFR). The D1 structural motif, located at the beginning of the D-helix of human CNTF, contains two amino acid residues, F152 and K155, which are conserved among all cytokines that signal through LIFR. The functional importance of these residues was assessed by… CONTINUE READING
    57 Citations
    Affinity Maturation of Leukemia Inhibitory Factor and Conversion to Potent Antagonists of Signaling*
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