Identification of cellular targets involved in cardiac failure caused by PKI in oncology: an approach combining pharmacovigilance and pharmacodynamics.

@article{Campaigno2017IdentificationOC,
  title={Identification of cellular targets involved in cardiac failure caused by PKI in oncology: an approach combining pharmacovigilance and pharmacodynamics.},
  author={Emilie Patras de Campaigno and Emmanuelle Bondon-Guitton and Guy Laurent and François Montastruc and Jean-Louis Montastruc and Maryse Lapeyre-Mestre and Fabien Despas},
  journal={British journal of clinical pharmacology},
  year={2017},
  volume={83 7},
  pages={
          1544-1555
        }
}
AIMS The aims of the present study were to evaluate the risk of cardiac failure (CF) associated with 15 anticancer protein kinase inhibitors (PKIs) through a case/noncase analysis and to identify which PK(s) and pathways are involved in PKI-induced CF. METHODS In order to evaluate the risk of CF, adjusted reporting odds ratios (aRORs) were calculated for… CONTINUE READING