Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line.

@article{Dyk2003IdentificationOC,
  title={Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line.},
  author={Derek D Van Dyk and David R Misztal and Marc R. Wilkins and James A Mackintosh and Anne Poljak and Jodie C Varnai and Erdahl T. Teber and Bradley J Walsh and Peter P. Gray},
  journal={Proteomics},
  year={2003},
  volume={3 2},
  pages={147-56}
}
A proteomics approach was used to identify the proteins potentially implicated in the cellular response concomitant with elevated production levels of human growth hormone in a recombinant Chinese hamster ovary (CHO) cell line following exposure to 0.5 mM butyrate and 80 microM zinc sulphate in the production media. This involved incorporation of two… CONTINUE READING