Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice.

@article{Allen2002IdentificationOC,
  title={Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice.},
  author={Jeremy P. Allen and Alison J. Canty and Stefan Schulz and Patrick P. A. Humphrey and Piers C. Emson and Heather M Young},
  journal={The Journal of comparative neurology},
  year={2002},
  volume={454 3},
  pages={
          329-40
        }
}
Somatostatin is found in neurons and endocrine cells in the gastrointestinal tract. The actions of somatostatin are mediated by a family of G-protein-coupled receptors that compose five subtypes (SSTR1-5), each of which is encoded by a separate gene. lacZ "knockin" mice, in which the reporter gene lacZ was engineered into the genomic locus of Sstr2 by gene targeting, were used to examine the expression pattern of Sstr2 and identify potential targets for neurally released and hormonal… CONTINUE READING
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