Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.

@article{Shimojima2012IdentificationOC,
  title={Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.},
  author={Masayuki Shimojima and Ute Stroeher and Hideki Ebihara and Heinz Feldmann and Yoshihiro Kawaoka},
  journal={Journal of virology},
  year={2012},
  volume={86 4},
  pages={2067-78}
}
Although O-mannosylated dystroglycan is a receptor for Lassa virus, a causative agent of Lassa fever, recent findings suggest the existence of an alternative receptor(s). Here we identified four molecules as receptors for Lassa virus: Axl and Tyro3, from the TAM family, and dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and liver and lymph node sinusoidal endothelial calcium-dependent lectin (LSECtin), from the C-type lectin family. These molecules… CONTINUE READING