Identification of-cell-specific insulin gene transcription factor RIPE 3 b 1 as mammalian MafA

Abstract

Of the three critical enhancer elements that mediate -cell-specific and glucose-responsive expression of the insulin gene, only the identity of the transcription factor binding to the RIPE3b element (RIPE3b1) has remained elusive. Using a biochemical purification approach, we have identified the RIPE3b1 factor as a mammalian homologue of avian MafA/L-Maf… (More)

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