Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis

@inproceedings{Qin2009IdentificationOC,
  title={Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis},
  author={Qiaoping Qin and Emily McCallum and Quentin Kaas and Jan Suda and Ivana Saska and David J. Craik and Joshua S Mylne},
  booktitle={BMC Genomics},
  year={2009}
}
Cyclotides are a family of circular peptides that exhibit a range of biological activities, including anti-bacterial, cytotoxic, anti-HIV activities, and are proposed to function in plant defence. Their high stability has motivated their development as scaffolds for the stabilisation of peptide drugs. Oldenlandia affinis is a member of the Rubiaceae (coffee) family from which 18 cyclotides have been sequenced to date, but the details of their processing from precursor proteins have only begun… CONTINUE READING
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