Identification of candidate tumour suppressor gene loci for Hodgkin and Reed-Sternberg cells by characterisation of homozygous deletions in classical Hodgkin lymphoma cell lines.

@article{Giefing2008IdentificationOC,
  title={Identification of candidate tumour suppressor gene loci for Hodgkin and Reed-Sternberg cells by characterisation of homozygous deletions in classical Hodgkin lymphoma cell lines.},
  author={Maciej Giefing and Joachim Arnemann and Jos{\'e} Ignacio Mart{\'i}n-Subero and Inga Niel{\"a}nder and Stefanie Bug and Sylvia Hartmann and Norbert K. Arnold and Enrico Tiacci and Matthias Frank and Martin-Leo Hansmann and Ralf K{\"u}ppers and Reiner Siebert},
  journal={British journal of haematology},
  year={2008},
  volume={142 6},
  pages={916-24}
}
Several tumour suppressor genes (TSG) have been identified as a result of mapping homozygous deletions in cancer cells. To identify putative TSG involved in the pathogenesis of classical Hodgkin lymphoma (cHL), we investigated four cHL cell lines (L428, HDLM2, KMH2, L1236) using four different array-Comparative Genomic Hybridisation (array-CGH) platforms and focused on high resolution identification of homozygous deletions. Out of 79 candidate regions of bi-allelic loss identified by array-CGH… CONTINUE READING

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Molecular karyotypes of Hodgkin and Reed-Sternberg cells at disease onset reveal distinct copy number alterations in chemosensitive versus refractory Hodgkin lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2011
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