Identification of candidate genes on chromosome band 20q12 by physical mapping of translocation breakpoints found in myeloid leukemia cell lines

@article{Macgrogan2001IdentificationOC,
  title={Identification of candidate genes on chromosome band 20q12 by physical mapping of translocation breakpoints found in myeloid leukemia cell lines},
  author={Donal Macgrogan and Sara Alvarez and Tony R Deblasio and Suresh C. Jhanwar and Stephen Nimer},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={4150-4160}
}
Deletions of the long arm of chromosome 20 have been reported in a wide range of myeloid disorders and may reflect loss of critical tumor suppressor gene(s). To identify such candidate genes, 65 human myeloid cell line DNAs were screened by polymerase chain reaction (PCR) for evidence of allelic loss at 39 highly polymorphic loci on the long arm of chromosome 20. A mono-allelic pattern was present in eight cell lines at multiple adjacent loci spanning the common deleted regions (CDRs… CONTINUE READING

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