Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains.

  title={Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains.},
  author={Lucinda G. Carr and Mark W Kimpel and Tiebing Liang and Jeanette N. McClintick and Kevin Mccall and Melissa Morse and Howard J. Edenberg},
  journal={Alcoholism, clinical and experimental research},
  volume={31 7},
BACKGROUND A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP and iNP rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol… CONTINUE READING


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