Identification of calpastatin and mu-calpain and studies of their association in pulmonary smooth muscle mitochondria.

@article{Kar2007IdentificationOC,
  title={Identification of calpastatin and mu-calpain and studies of their association in pulmonary smooth muscle mitochondria.},
  author={Pulak Kar and Tapati Chakraborti and Soumitra Roy and Rajdeep Choudhury and Sajal Chakraborti},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={466 2},
  pages={290-9}
}
Using calpastatin antibody we have identified a 145 kDa major band along with two relatively minor bands at 120 kDa and 110 kDa calpastatin molecules in bovine pulmonary artery smooth muscle mitochondria. To the best of our knowledge this is first report regarding the identification of calpastatin in mitochondria. We also demonstrated the presence of micro-calpain in the mitochondria by immunoblot and casein zymogram studies. Immunoblot studies identified two major bands corresponding to the 80… CONTINUE READING

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