Identification of calcium release-triggering and blocking regions of the II-III loop of the skeletal muscle dihydropyridine receptor.

@article{ElHayek1995IdentificationOC,
  title={Identification of calcium release-triggering and blocking regions of the II-III loop of the skeletal muscle dihydropyridine receptor.},
  author={Roque El-Hayek and Bozena A Antoniu and Jie Wang and Susan L. Hamilton and Noriaki Ikemoto},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 38},
  pages={22116-8}
}
In an attempt to identify and characterize functional domains of the rabbit skeletal muscle dihydropyridine receptor alpha 1 subunit II-III loop, we synthesized several peptides corresponding to different regions of the loop: peptides A, B, C, C1, C2, D (cf. Fig. 1). Peptide A (Thr671-Leu690) activated [3H]ryanodine binding to, and induced Ca2+ release from, rabbit skeletal muscle triads, but none of the other peptides had such effects. Peptide A-induced Ca2+ release and activation of ryanodine… CONTINUE READING

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