Identification of calcium channels involved in neuronal injury in rat hippocampal slices subjected to oxygen and glucose deprivation.

@article{Small1997IdentificationOC,
  title={Identification of calcium channels involved in neuronal injury in rat hippocampal slices subjected to oxygen and glucose deprivation.},
  author={Daniel L. Small and Robert Monette and Alastair M Buchan and P. D. Morley},
  journal={Brain research},
  year={1997},
  volume={753 2},
  pages={209-18}
}
The presynaptic Ca2+-influx affecting glutamate release during neuropathological processes is mediated via voltage-sensitive calcium channels (VSCCs). There is controversy, however, over the fractional contribution of the specific channel types involved. We have addressed this by investigating the protective effects of various VSCC blockers on oxygen and glucose-deprived rat hippocampal slices. The viability of treated and non-treated slices was assayed electrophysiologically by measuring the… CONTINUE READING

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