Identification of cadherin tyrosine residues that are phosphorylated and mediate Shc association.

@article{Xu1999IdentificationOC,
  title={Identification of cadherin tyrosine residues that are phosphorylated and mediate Shc association.},
  author={Y L Xu and Graham F Carpenter},
  journal={Journal of cellular biochemistry},
  year={1999},
  volume={75 2},
  pages={264-71}
}
Previously, we reported association of the adaptor protein Shc through its SH2 domain with the cytoplasmic domain of the adhesion molecule cadherin (Xu et al. [1997] J. Biol. Chem. 272:13463-13466). This association was dependent on tyrosine phosphorylation of cadherin and could be modulated by extracellular Ca(2+) and epidermal growth factor in intact cells. There are six tyrosine residues in the cytoplasmic domain of cadherin. To define the tyrosine residue(s) that mediate Shc recognition… CONTINUE READING
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