Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells.

@article{Wen1999IdentificationOC,
  title={Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells.},
  author={X Y Wen and A. Keith Stewart and Roy R Sooknanan and Gail Henderson and Teresa S. Hawley Robert G. Hawley and Andreas M. Reimold and L. H. Glimcher and Heinz Baumann and Lawrence T. Malek and Robert G. Hawley},
  journal={International journal of oncology},
  year={1999},
  volume={15 1},
  pages={173-8}
}
Interleukin-6 (IL-6) is implicated in the in vivo proliferation of malignant plasma cells in multiple myeloma. To define the molecular basis of the IL-6-induced mitogenic response in myeloma cells, we applied STAR (subtractive transcriptional amplification of mRNA), a new differential expression analysis technology, to isolate mRNAs preferentially expressed in IL-6-treated versus untreated cultures of the factor-responsive myeloma cell line U266. From the resulting collection of STAR clones… CONTINUE READING
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