Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice.

@article{Noan2006IdentificationOB,
  title={Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice.},
  author={Daniela Noa{\'i}n and Mar{\'i}a Elena Avale and Carolina Wedemeyer and Daniel Horacio Calvo and Marcela Peper and Marcelo Gonçalves Rubinstein},
  journal={The European journal of neuroscience},
  year={2006},
  volume={24 9},
  pages={2429-38}
}
The dopamine D4 receptor (D4R) has received considerable interest because of its higher affinity for atypical antipsychotics, the extremely polymorphic nature of the human gene and the genetic association with attention deficit and hyperactivity disorder (ADHD). Several efforts have been undertaken to determine the D4R expression pattern in the brain using immunohistochemistry, binding autoradiography and in situ hybridization, but the overall published results present large discrepancies. Here… CONTINUE READING

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