Identification of bipotential progenitor cells in human liver development.

  title={Identification of bipotential progenitor cells in human liver development.},
  author={Yoshisumi Haruna and Ken Saito and Sara Spaulding and Michael Andrew Nalesnik and Michael A. Gerber},
  volume={23 3},
Intermediate filament proteins have been reported to be expressed in a cell lineage-specific manner during morphogenesis. We studied the expression of cytokeratin (CK)14, CK19, and vimentin and of the hepatocyte-specific HepPar1 antigen during the development of human liver. Nineteen fetal livers (gestational ages 4 to 40 weeks), 3 normal infant livers, and 3 normal adult livers were studied by immunoperoxidase staining of paraffin sections with monoclonal anti-CK19, anti-vimentin, and HepPar1… CONTINUE READING
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