Identification of bipotential progenitor cells in human liver regeneration.

  title={Identification of bipotential progenitor cells in human liver regeneration.},
  author={Salima Haque and Yoshisumi Haruna and Ken Saito and Michael Andrew Nalesnik and Ercem Atillasoy and Swan N. Thung and Michael A. Gerber},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={75 5},
Recent studies, including our own, suggest that intermediate filament proteins, particularly bile duct-specific cytokeratin 19 (CK19) and the hepatocyte-specific HepPar1 antigen define the developmental stages of hepatic progenitor cells during liver morphogenesis. We hypothesized that the HepPar1+ CK19+ progenitor cells are activated during human liver regeneration after massive hepatic necrosis and proliferate with the formation of so-called ductular hepatocytes or neocholangioles. We… CONTINUE READING


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