Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)

@article{Doate2008IdentificationOB,
  title={Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)},
  author={Fernando Do{\~n}ate and Jos{\'e} C Juarez and Mark E Burnett and Mari Manuia and Xiaojun Guan and David E. Shaw and Eric L. P. Smith and C Timucin and Marc J Braunstein and Olcay A. Batuman and Andrew P. Mazar},
  journal={British Journal of Cancer},
  year={2008},
  volume={98},
  pages={776 - 783}
}
Tetrathiomolybdate (choline salt; ATN-224), a specific, high-affinity copper binder, is currently being evaluated in several phase II cancer trials. ATN-224 inhibits CuZn superoxide dismutase 1 (SOD1) leading to antiangiogenic and antitumour effects. The pharmacodynamics of tetrathiomolybdate has been followed by tracking ceruloplasmin (Cp), a biomarker for systemic copper. However, at least in mice, the inhibition of angiogenesis occurs before a measurable decrease in systemic copper is… CONTINUE READING

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