Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.

@article{Tan2010IdentificationOB,
  title={Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.},
  author={Sandra Min-Li Tan and Feng Li and Peramaiyan Rajendran and Alan Prem Kumar and Kam Man Hui and Gautam Sethi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={334 1},
  pages={285-93}
}
The activation of signal transducer and activator of transcription 3 (STAT3) has been linked with the proliferation, survival, invasion, and angiogenesis of a variety of human cancer cells, including hepatocellular carcinoma (HCC). Agents that can suppress STAT3 activation have potential for the prevention and treatment of HCC. In this study, we tested an agent, beta-escin, for its ability to suppress STAT3 activation. We found that beta-escin, a pentacyclic triterpenoid, inhibited both… CONTINUE READING

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