Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.

@article{PalkaHamblin2010IdentificationOB,
  title={Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.},
  author={Helena L. Palka-Hamblin and Jessica J. Gierut and Wenjun Bie and Patrick M Brauer and Yu Zheng and John M. Asara and Angela L. Tyner},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 2},
  pages={
          236-45
        }
}
Disruption of the gene encoding protein tyrosine kinase 6 (PTK6) leads to increased growth, impaired enterocyte differentiation and higher levels of nuclear beta-catenin in the mouse small intestine. Here, we demonstrate that PTK6 associates with nuclear and cytoplasmic beta-catenin and inhibits beta-catenin- and T-cell factor (TCF)-mediated transcription. PTK6 directly phosphorylates beta-catenin on Tyr64, Tyr142, Tyr331 and/or Tyr333, with the predominant site being Tyr64. However, mutation… CONTINUE READING
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