Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

@inproceedings{Robertson2016IdentificationOB,
  title={Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen},
  author={Anne L. Robertson and Nikolay V. Ogryzko and Katherine M. Henry and Catherine A Loynes and Matthew J Foulkes and Marco M. Meloni and Xingang Wang and Christopher Ford and Malcolm Jackson and Philip W Ingham and Heather L Wilson and Stuart N. Farrow and Roberto Solari and Roderick John Flower and Simon Jones and Moira K B Whyte and Stephen A Renshaw},
  booktitle={Disease models & mechanisms},
  year={2016}
}
Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or reverse migration. If the inflammatory response is not well-regulated, persistent neutrophils can cause damage to host tissues and contribute to the pathogenesis of chronic inflammatory diseases, which respond poorly to current treatments. It is… CONTINUE READING

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