Identification of axon-enriched microRNAs localized to growth cones of cortical neurons.

@article{Sasaki2014IdentificationOA,
  title={Identification of axon-enriched microRNAs localized to growth cones of cortical neurons.},
  author={Yukio Sasaki and Christina Gross and Lei Xing and Yoshio Goshima and Gary Jonathan Bassell},
  journal={Developmental neurobiology},
  year={2014},
  volume={74 3},
  pages={397-406}
}
There is increasing evidence that localized mRNAs in axons and growth cones play an important role in axon extension and pathfinding via local translation. A few studies have revealed the presence of microRNAs (miRNAs) in axons, which may control local protein synthesis during axon development. However, so far, there has been no attempt to screen for axon-enriched miRNAs and to validate their possible localization to growth cones of developing axons from neurons of the central nervous system… CONTINUE READING

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